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There are 19 words containing 2E, 2M, S and X

EXTREMISMextremism n. Extreme ideas or actions, primarily in politics or religion.
EXTREMISM n. the taking of an extreme position.
EXTREMUMSextremums n. Plural of extremum.
EXTREMUM n. (Latin) a maximum or minimum of a mathematical function.
MYXEDEMASmyxedemas n. Plural of myxedema.
MYXEDEMA n. (US) a skin disease, marked by swelling and dryness, due to insufficient thyroid secretion, also MYXOEDEMA.
EXTREMISMSextremisms n. Plural of extremism.
EXTREMISM n. the taking of an extreme position.
HEXAMERISMhexamerism n. Six-part radial symmetry.
HEXAMERISM n. the state of being hexamerous.
METAXYLEMSmetaxylems n. Plural of metaxylem.
METAXYLEM n. a part of the primary xylem.
MYXOEDEMASmyxoedemas n. Plural of myxoedema.
MYXOEDEMA n. a skin disease, marked by swelling and dryness, due to insufficient thyroid secretion, also MYXEDEMA.
HEXAMERISMSHEXAMERISM n. the state of being hexamerous.
MYXOMYCETESmyxomycetes n. Plural of myxomycete.
Myxomycetes prop.n. A taxonomic class within the phylum Amoebozoa – Myxogastrea.
MYXOMYCETE n. slime mould.
MYXEDEMATOUSmyxedematous adj. Relating to, or exhibiting, myxedema.
MYXEDEMATOUS adj. (US) relating to myxedema, a skin disease, also MYXOEDEMATOUS.
XERANTHEMUMSxeranthemums n. Plural of xeranthemum.
XERANTHEMUM n. any plant of the Xeranthemum genus of plants of southern Europe, belonging to the thistle family.
AXISYMMETRIESaxisymmetries n. Plural of axisymmetry.
AXISYMMETRY n. the state of being axisymmetric.
MYXOEDEMATOUSmyxoedematous adj. Alternative form of myxedematous.
MYXOEDEMATOUS adj. relating to myxoedema, a skin disease, also MYXEDEMATOUS.
EXCOMMUNICATESexcommunicates n. Plural of excommunicate.
excommunicates v. Third-person singular simple present indicative form of excommunicate.
EXCOMMUNICATE v. to formally exclude someone from a group or community, esp. from a religious community.
HEXAMETHONIUMShexamethoniums n. Plural of hexamethonium.
HEXAMETHONIUM n. either of two compounds used as ganglionic blocking agents in the treatment of hypertension.
CHEMOTAXONOMIESchemotaxonomies n. Plural of chemotaxonomy.
CHEMOTAXONOMY n. the classification of plants and animals based on similarities and differences in biochemical composition.
DEXAMPHETAMINESDEXAMPHETAMINE n. the dextrorotatory isomer of amphetamine, used as a stimulant.
EXPERIMENTALISMexperimentalism n. An experimental practice or tendency, especially in the arts.
experimentalism n. (Philosophy) An empirical or pragmatic approach which emphasizes the importance of experimentation.
EXPERIMENTALISM n. reliance on or advocacy of experimental or empirical principles and procedures.
IMMUNOCOMPLEXESimmunocomplexes n. Plural of immunocomplex.
IMMUNOCOMPLEX n. a complex formed between an antibody and an antigen.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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