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There are 6 eight-letter words containing 2E, 2N and 2O

BOTONNEEBOTONNEE adj. having buds or knobs at the extremities, applied to a cross, also BOTONE, BOTONEE, BOTTONY.
CONENOSEconenose n. Conenose bug.
CONENOSE n. a bloodsucking insect.
ETHONONEETHONONE n. a toxic gas.
NONOBESEnonobese adj. (Medicine) Not obese; free of symptoms of obesity.
NONOBESE adj. not obese.
ONCOGENEoncogene n. (Oncology, genetics) Any gene that contributes to the conversion of a normal cell into a cancerous cell…
ONCOGENE n. a gene that causes a cell to become cancerous.
ROTENONErotenone n. (Chemistry) A toxic crystalline substance obtained from the roots of derris and related plants, widely…
ROTENONE n. an insecticide and fish-poison prepared from derris and other roots.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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