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There are 19 eight-letter words containing 2E, M, 2O and S

BORESOMEboresome adj. Marked by boredom; boring; uninteresting.
BORESOME adj. tedious, boring.
COELOMEScoelomes n. Plural of coelome.
COELOME n. (Greek) a body cavity in some animals, also COELOM, CELOM.
DOLESOMEdolesome adj. Doleful; dismal; gloomy.
DOLESOME adj. doleful, dismal.
EMOCORESEMOCORE n. a type of music combining traditional hard rock with personal and emotional lyrics, also EMO.
ENDOSOMEendosome n. (Biology) An endocytic vacuole through which molecules internalized during endocytosis pass en route to lysosomes.
ENDOSOME n. a cellular particle.
EXOSMOSEexosmose n. Archaic form of exosmosis.
EXOSMOSE n. osmosis outwards, i.e. away from the solution, also EXOSMOSIS.
EXPOSOMEexposome n. A measure of the effects of life-long environmental exposures on health.
EXPOSOME n. a collection of environmental factors, such as stress and diet, to which an individual is exposed and which can have an effect on health.
HOLESOMEholesome adj. Obsolete form of wholesome.
HOLESOME adj. (Spenser) wholesome, also HEALSOME, HOLESOM.
HOMEOSEShomeoses n. Plural of homeosis.
HOMEOSIS n. the assumption of the character of a corresponding member of another whorl or somite, also HOMOEOSIS.
JOKESOMEjokesome adj. Marked by joking or jocularity; joky; humorous.
JOKESOME adj. amusing.
LONESOMElonesome adj. Unhappy due to being alone; lonely.
lonesome n. (Informal) Oneself alone.
LONESOME adj. lonely.
LOVESOMElovesome adj. Worthy of love; having qualities that inspire love; lovable.
lovesome adj. (Now rare, chiefly Ireland) Affectionate; friendly.
lovesome adj. Lovable on account of beauty; lovely, beautiful.
MEROSOMEmerosome n. (Biology) Any of the segments of a segmented animal.
MEROSOME n. one of the serial segments of which a body is composed, also MEROME.
MESOSOMEmesosome n. A folded invagination in the plasma membrane of bacteria, produced by the chemical fixation techniques…
mesosome adj. Average-bodied; neither broad nor narrow in proportion to height or length.
MESOSOME n. a convoluted invagination of the cell wall in some bacteria.
MOONEYESmooneyes n. Plural of mooneye.
moon␣eyes n. Plural of moon eye.
moon␣eyes n. (Informal) A romantic look at someone; goo-goo eyes.
MOONSEEDmoonseed n. A twining plant of the genera Menispermum or Cocculus, in the family Menispermaceae.
MOONSEED n. a plant of genus Menispermum with lunate seeds.
MOONSHEEmoonshee n. Archaic spelling of munshi.
MOONSHEE n. (Hindi) a secretary, interpreter, also MUNSHI.
OENOMELSOENOMEL n. (Greek) an ancient Greek beverage, also OINOMEL.
SOMEONESsomeones n. Plural of someone.
someone's pron. Possessive case of someone.
someone's cont. Someone is.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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