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There are 13 eight-letter words containing 2E, 2M and 2S

EMMESHESemmeshes v. Third-person singular simple present indicative form of emmesh.
EMMESH v. to entangle, also ENMESH, IMMESH, INMESH.
IMMERSESimmerses v. Third-person singular simple present indicative form of immerse.
IMMERSE v. to plunge into a liquid, also IMMERGE.
IMMESHESimmeshes v. Third-person singular simple present indicative form of immesh.
IMMESH v. to entangle, as in, the meshes of a net, also ENMESH, EMMESH, INMESH.
MESDAMESmesdames n. Plural of madam.
mesdames n. Plural of madame.
Mesdames n. Plural of Madam.
MESOSOMEmesosome n. A folded invagination in the plasma membrane of bacteria, produced by the chemical fixation techniques…
mesosome adj. Average-bodied; neither broad nor narrow in proportion to height or length.
MESOSOME n. a convoluted invagination of the cell wall in some bacteria.
MESSMATEmessmate n. (Nautical) an associate with whom one shares a mess (eating place) on a ship.
messmate n. (Australia) Any of various eucalypts with rough bark, specifically Eucalyptus obliqua.
MESSMATE n. a person with whom one eats regularly.
MESTOMESMESTOME n. biological conducting tissue, also MESTOM.
MISDEEMSmisdeems v. Third-person singular simple present indicative form of misdeem.
MISDEEM v. to judge unfavourably.
MISHMEESMishmees n. Plural of Mishmee.
MISHMEE n. the bitter root stock of a plant, also MISHMI.
MISMEETSmismeets v. Third-person singular simple present indicative form of mismeet.
MISMEET v. to meet under unfortunate circumstances.
MISSEEMSmisseems v. Third-person singular simple present indicative form of misseem.
MISSEEM v. (Spenser) to be unbecoming to.
MOUSMEESmousmées n. Plural of mousmée.
MOUSMEE n. (Japanese) a Japanese girl, esp. a waitress, also MOUSME.
STEMMERSstemmers n. Plural of stemmer.
STEMMER n. a metal bar used to tamp down a charge in a blasting hole.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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