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There are 12 twelve-letter words containing 2E, 2M, P and U

EMPYREUMATICempyreumatic adj. (Obsolete, chemistry) Characteristic of empyreuma.
EMPYREUMATIC adj. relating to empyreuma, also EMPYREUMATICAL.
LUMPECTOMIESlumpectomies n. Plural of lumpectomy.
LUMPECTOMY n. the surgical removal of a lump, esp. in the breast, aka tylectomy.
MENISPERMUMSMENISPERMUM n. any plant of the moonseed genus Menispermum.
METACOMPUTERMETACOMPUTER n. a collection of computers that looks and functions like a single computer.
MUGWUMPERIESMUGWUMPERY n. the acts and views of a mugwump, a bolter from the Republican party in 1884; a political independent.
MUMBLETYPEGSMUMBLETYPEG n. a game of throwing knives to make them stick in the ground.
PAMPELMOUSESpampelmouses n. Plural of pampelmouse.
PAMPELMOUSE n. (Dutch) the shaddock or grapefruit, also PAMPELMOOSE, POMELO, POMPELMOOSE, POMPELMOUS, POMPELMOUSE, POMPELO, PUMELO, PUMMELO.
POMPELMOUSESpompelmouses n. Plural of pompelmous.
pompelmouses n. Plural of pompelmouse.
POMPELMOUSE n. (Dutch) the shaddock or grapefruit, also PAMPELMOOSE, PAMPELMOUSE, POMELO, POMPELMOOSE, POMPELMOUS, POMPELO, PUMELO, PUMMELO.
SEMPERVIVUMSsempervivums n. Plural of sempervivum.
SEMPERVIVUM n. a plant, the houseleek.
SEMPITERNUMSsempiternums n. Plural of sempiternum.
SEMPITERNUM n. (obsolete) a durable woollen cloth.
SUPERPREMIUMsuperpremium adj. Of greatly superior quality, beyond premium.
superpremium n. A product or brand of greatly superior quality, beyond premium.
SUPERPREMIUM n. a very large premium.
UNEMPLOYMENTunemployment n. The state of having no job; joblessness.
unemployment n. The phenomenon of joblessness in an economy.
unemployment n. The level of joblessness in an economy, often measured as a percentage of the workforce.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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