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There are 5 twelve-letter words containing 2E, H, 2R and X

HYPEROREXIASHYPEROREXIA n. compulsive overeating.
HYPERPYREXIAhyperpyrexia n. (Medicine) An excessive and unusual elevation of set body temperature greater than or equal to 41°C…
HYPERPYREXIA n. an extremely high fever, with a temperature of 41 degrees Centigrade or above, also HYPERTHERMY.
INHERITRIXESinheritrixes n. Plural of inheritrix.
INHERITRIX n. a female inheritor, also INHERITRESS.
XEROGRAPHERSxerographers n. Plural of xerographer.
XEROGRAPHER n. one who practises xerography.
XEROGRAPHIESXEROGRAPHY n. a nonchemical photographic process in which the plate is sensitized electrically and developed by dusting with electrically-charged fine powder.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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