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There are 16 twelve-letter words containing 3E, 2F and I

DECAFFEINATEdecaffeinate v. (Transitive) To remove the caffeine from something (especially from coffee).
DECAFFEINATE v. to remove caffeine from.
DIFFERENCIEDDIFFERENCY v. to make or perceive a difference in, also DIFFERENCE.
DIFFERENCIESDIFFERENCY v. to make or perceive a difference in, also DIFFERENCE.
DIFFERENTIAEdifferentiae n. Plural of differentia.
DIFFERENTIA n. a property which distinguishes one from another.
EFFEMINACIESeffeminacies n. Plural of effeminacy.
EFFEMINACY n. the quality of being effeminate.
EFFEMINATELYeffeminately adv. In an effeminate manner.
EFFEMINATE adv. womanish.
EFFERVESCINGeffervescing v. Present participle of effervesce.
effervescing n. Effervescence.
EFFERVESCE v. to bubble, hiss, and foam as gas escapes.
EFFICIENCIESefficiencies n. Plural of efficiency.
EFFICIENCY n. the quality of being efficient, also EFFICIENCE.
EFFRONTERIESeffronteries n. Plural of effrontery.
EFFRONTERY n. shameless boldness; presumptuousness.
EFFUSIOMETEReffusiometer n. A device that measures the rate of effusion of a gas.
EFFUSIOMETER n. an instrument for comparing the molecular weights of gases.
EFFUSIVENESSeffusiveness n. The state of being effusive.
EFFUSIVENESS n. the state of being effusive.
INDIFFERENCEindifference n. The state of being indifferent.
indifference n. Unbiased impartiality.
indifference n. Unemotional apathy.
INEFFACEABLEineffaceable adj. Incapable of being effaced.
INEFFACEABLE adj. not effaceable.
NONEFFECTIVEnoneffective adj. Not effective.
noneffective adj. (Military) Not able to assume active duty.
noneffective n. A member of the military who is unable to assume active duty.
OVEREFFUSIVEovereffusive adj. Excessively effusive.
OVEREFFUSIVE adj. excessively effusive.
WHIFFLETREESwhiffletrees n. Plural of whiffletree.
WHIFFLETREE n. the crosspiece of a carriage to which harnesses are attached, also SINGLETREE, SWINGLETREE, SWINGTREE, WHIPPLETREE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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