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There are 4 ten-letter words containing 2E, I, P and 2U

EPINEURIUMepineurium n. (Anatomy) The connective tissue framework and sheath of a nerve which bind together the nerve bundles…
EPINEURIUM n. the connective tissue framework and sheath of a nerve.
PERRUQUIERperruquier n. A maker of perukes or wigs.
PERRUQUIER n. (French) a wigmaker.
PUERPERIUMpuerperium n. (Obstetrics) The period of time lasting around a month immediately following childbirth, when the mother’s…
PUERPERIUM n. (Latin) the condition immediately following childbirth.
UNEQUIPPEDunequipped v. Simple past tense and past participle of unequip.
unequipped adj. Without equipment.
unequipped adj. Not given the appropriate tools to deal with a situation.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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