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There are 6 words containing E, 2F, S and Z

AFFLUENZASaffluenzas n. (Rare) plural of affluenza.
AFFLUENZA n. a malaise said to affect affluent young people, characterised by guilt feelings.
EFFEMINIZESeffeminizes v. Third-person singular simple present indicative form of effeminize.
EFFEMINIZE v. (archaic) to make effeminate.
SCHIZOAFFECTIVEschizoaffective adj. (Psychiatry) Combining the symptoms of schizophrenia with those of bipolar disorder.
schizoaffective n. A person who has a schizoaffective disorder.
ZAFFERSzaffers n. Plural of zaffer.
ZAFFER n. (Italian) an impure oxide of cobalt, also ZAFFAR, ZAFFIR, ZAFFRE.
ZAFFRESzaffres n. Plural of zaffre.
ZAFFRE n. (Italian) an impure oxide of cobalt, also ZAFFAR, ZAFFER, ZAFFIR.
ZIFFIUSESZIFFIUS n. (Spenser) a sea-monster, perhaps a swordfish.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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