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There are 7 eight-letter words containing 2E, 2N and X

ANNEXUREannexure n. (UK) The process of annexing.
annexure n. (UK) Something annexed.
annexure n. (Especially India and UK law, otherwise dated) An appendix or attachment to a document.
ENDEXINEENDEXINE n. an inner layer of the exine, the tough outer wall of a pollen grain.
EXPONENTexponent n. One who expounds, represents or advocates.
exponent n. (Mathematics) The number by which a value (called the base) is said to be raised to a power in exponentiation…
exponent n. (Mathematics, obsolete) The degree to which the root of a radicand is found, for example, the 2 in 2]𝑟=𝑏.
NEXTNESSnextness n. The fact or condition of immediate succession or proximity; the quality of being next.
NEXTNESS n. the state of being next.
XANTHENExanthene n. (Organic chemistry) any of a group of tricyclic heterocycles (dibenzopyrans) that are the basis for…
XANTHENE n. a white crystalline compound of carbon, hydrogen and oxygen, from which dyestuffs are derived.
XENOGENYxenogeny n. Xenogenesis.
XENOGENY n. the production of offspring totally different from the parent.
XENURINExenurine n. Any armadillo of the former genus Xenurus (now Cabassous).
XENURINE n. any armadillo of the genus Xenurus.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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