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There are 3 eight-letter words containing 2E, 2M and X

EXEMPLUMexemplum n. An example.
exemplum n. A story demonstrating a moral point; a parable.
EXEMPLUM n. (Latin) a short story or anecdote with a moral.
EXTREMUMextremum n. (Mathematics) A point, or value, which is a maximum or a minimum.
EXTREMUM n. (Latin) a maximum or minimum of a mathematical function.
MYXEDEMAmyxedema n. (Pathology) A form of cutaneous and dermal edema that is secondary to increased deposition of connective…
MYXEDEMA n. (US) a skin disease, marked by swelling and dryness, due to insufficient thyroid secretion, also MYXOEDEMA.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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