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There are 15 six-letter words containing 2E, N, P and R

NEPERSnepers n. Plural of neper.
NEPER n. a unit for expressing the ratio of two currents or voltages.
OPENERopener n. A person who opens something.
opener n. A device that opens something; specifically a tin-opener/can-opener, or a bottle opener.
opener n. (In combination) An establishment that opens.
PANEERpaneer n. A soft, non-matured, Indian cheese.
PANEER n. (Hindi) a soft white cheese used in Indian cookery.
PENNERpenner n. One who pens; a writer.
penner n. (Historical) A case for holding pens.
Penner prop.n. A surname.
PERCENPERCEN v. (Spenser) to pierce.
PEREONpereon n. Alternative form of pereion.
PEREON n. a crustacean's thorax, also PEREION, PERAEON.
PERNEDPERN v. to move with a spiralling motion.
PERONEperone n. (Anatomy, obsolete) The fibula.
Perone prop.n. A surname.
-perone suff. (Pharmacology) Used to form names of 4’-fluoro-4-piperidinobutyrophenone derivatives used as tranquilizers…
PREENSpreens v. Third-person singular simple present indicative form of preen.
PREEN v. to clean and arrange the feathers with the beak.
PREMENpremen n. Plural of preman.
PREMAN n. a hypothetical ancestor of man.
PYRENEpyrene n. (Chemistry) A polycyclic aromatic hydrocarbon containing four fused benzene rings; first isolated from coal tar.
pyrene n. (Botany) A pyrena; a nutlet resembling a seed, or the kernel/stone of a drupe.
PYRENE n. the hard covering of the kernel of certain fruits.
REOPENreopen v. (Transitive) To open (something) again.
reopen v. (Intransitive) To open again.
REOPEN v. to open again.
REPENTrepent v. (Intransitive) To feel pain, sorrow, or regret for what one has done or omitted to do; the cause for…
repent v. (Theology, intransitive) To be sorry for sin as morally evil, and to seek forgiveness; to cease to practice…
repent v. (Transitive) To feel pain on account of; to remember with sorrow.
REPINErepine v. (Transitive) To fail; to wane.
repine v. (Intransitive, now literary) To complain; to regret.
REPINE v. to express discontent.
REPONErepone v. To replace.
repone v. To reply.
REPONE v. to restore to office.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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