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There are 6 six-letter words containing 2E, F, S and U

DEFUSEdefuse v. (Transitive) To remove the fuse from (A bomb, etc.).
defuse v. (Transitive, figurative) To make less dangerous, tense, or hostile.
defuse v. (Obsolete) To disorder; to make shapeless.
EFFUSEeffuse adj. Poured out freely; profuse.
effuse adj. Disposed to pour out freely; prodigal.
effuse adj. (Botany) Spreading loosely, especially on one side.
FESCUEfescue n. (Countable) A straw, wire, stick, etc., used chiefly to point out letters to children when learning to read.
fescue n. A hardy grass commonly used to border golf fairways in temperate climates. Any member of the genus Festuca.
fescue n. (Countable) An instrument for playing on the harp; a plectrum.
FUSEESfusees n. Plural of fusee.
FUSEE n. (French) a large-headed friction match, also FUZEE.
FUZEESfuzees n. Plural of fuzee.
FUZEE n. (French) a match with a long oval head for outdoor use, also FUSEE.
REFUSErefuse adj. Discarded, rejected.
refuse n. Collectively, items or material that have been discarded; rubbish, garbage.
refuse v. (Transitive) To decline (a request or demand).

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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