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There are 3 twelve-letter words containing E, F, 2O and X

DORSIFLEXIONdorsiflexion n. (Medicine) Flexion in the dorsal direction.
DORSIFLEXION n. a bending backwards; a bending of the back.
EXFOLIATIONSexfoliations n. Plural of exfoliation.
EXFOLIATION n. the process by which concentric scales, plates, or shells of rock are stripped or spall from the bare surface of a large rock mass.
RETROFLEXIONretroflexion n. The act of retroflexing; the state of being retroflexed.
RETROFLEXION n. the state of being bent back, also RETROFLECTION.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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