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There are 5 five-letter words containing E, 2I and N

GENIIgenii n. (Roman mythology) plural of genius; guardian spirits.
genii n. Plural of genie.
GENIUS n. (Latin) an exceptional natural aptitude.
IMINEimine n. (Organic chemistry) Any of a class of organic nitrogen compounds having the general formula R2C=NR;…
IMINE n. a chemical compound.
INDIEindie adj. Independent; from outside the mainstream.
indie n. An independent publisher.
indie n. A work released by an independent publisher.
NISEInisei n. One whose parents were Japanese immigrants, especially to North or South America.
Nisei n. A person born outside of Japan of parents who were born in Japan.
NISEI n. (Japanese) a second-generation Japanese immigrant.
NIXIEnixie n. A female nix, a water-spirit.
nixie n. A piece of mail returned as undeliverable.
NIXIE n. a female nix or malignant water-spirit, also NIXY.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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