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There are 16 five-letter words containing E, H, M and S

CHEMSchems n. Plural of chem.
CHEM n. (short for) a chemistry class or course.
HAEMShaems n. Plural of haem.
HAEM n. the pigment combined with protein in haemoglobin, also HEME.
HAMEShames n. Plural of hame.
hames n. (Ireland, colloquial) A mess.
Hames prop.n. A surname.
HELMShelms n. Plural of helm.
helms v. Third-person singular simple present indicative form of helm.
Helms prop.n. A surname.
HEMEShemes n. Plural of heme.
HEME n. a component of hemoglobin, also HAEM.
HEMPShemps n. Plural of hemp.
Hemps prop.n. Plural of Hemp.
HEMP n. a plant yielding a coarse fibre and an oil.
HERMSherms n. Plural of herm.
HERM n. a type of statue, also HERMA.
HIEMSHIEMS n. (Shakespeare) winter.
HOMEShomes n. Plural of home.
homes n. (Slang) Alternative spelling of holmes.
homes v. Third-person singular simple present indicative form of home.
MECHSmechs n. Plural of mech.
mechs. n. Plural of mech.
MECH n. (short for) mechanic.
MENSHMENSH v. (colloquial) to mention.
MESHYmeshy adj. Formed with meshes; netted.
MESHY adj. formed like network.
METHSmeths n. (UK, Canada, Australia, New Zealand, informal) methylated spirits.
meths n. (Geordie) plural of meth.
METH n. a stimulant drug.
SHAMEshame n. Uncomfortable or painful feeling due to recognition or consciousness of one’s own impropriety or dishonor…
shame n. Something to regret.
shame n. Reproach incurred or suffered; dishonour; ignominy; derision.
SHMEKSHMEK n. (Yiddish) a taste or sniff; heroin, also SCHMECK.
SHMOEshmoe n. Alternative spelling of schmo.
SHMOE n. (Yiddish) a stupid or boring person, also SCHMO, SCHMOE, SHMO.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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