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There are 3 four-letter words containing E, I, N and S

NIESNies prop.n. Plural of Nie.
NIEs n. Plural of NIE.
NY v. to approach, also NIE, NIGH, NYE.
SIENsien n. Obsolete spelling of scion.
SIEN n. (Shakespeare) a scion, also CION, SEYEN, SIENT, SYEN.
SINEsine n. (Trigonometry, mathematics) In a right triangle, the ratio of the length of the side opposite an angle…
SINE n. (Genetics) Acronym of short interspersed element, a type of retrotransposon in genomics.
SINE n. Acronym of selective inhibitors of nuclear export, a drug for epithelioid sarcoma.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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