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There are 4 four-letter words containing E, N and X

EXONexon n. An officer of the Queen’s Body Guard of the Yeomen of the Guard.
exon n. (Genetics) A region of a transcribed gene present in the final functional RNA molecule.
Exon prop.n. A surname.
NEXTnext adj. Nearest in place or position, having nothing similar intervening; adjoining.
next adj. Nearest in order, succession, or rank; immediately following (or sometimes preceding) in order.
next adj. (Chiefly law) Nearest in relationship. (See also next of kin.)
NIXEnixe n. Alternative spelling of nixie (“female water-elf”).
NIX n. a water sprite.
OXENoxen n. Plural of ox.
oxen adj. Of, relating to, or resembling an ox; oxlike.
OX n. a hoofed mammal.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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