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There are 12 words containing 2D, E, I, 2M, R and S

DEMIREPDOMS	• DEMIREPDOM n. the state of being a demirep, a woman of doubtful reputation.
DESMODROMIC	• desmodromic adj. (Of a mechanical device) Having different controls for its actuation in different directions, especially… • DESMODROMIC adj. denoting a system, used in some motorcycle and racing car engines, that employs e.g. cams, rockers, etc. to ensure that the opening and closing of valves, when the vehicle is at high speed, is fully controlled.
DISIMMURED	• DISIMMURE v. to liberate; to release from walls.
DISMEMBERED	• dismembered v. Simple past tense and past participle of dismember. • dismembered adj. From which the limbs have been removed. • DISMEMBER v. to cut or tear a body limb from limb.
DISREMEMBERED	• disremembered v. Simple past tense and past participle of disremember. • DISREMEMBER v. to forget.
LAMPADEDROMIES	• LAMPADEDROMY n. a foot race with lighted torches, esp. a relay race in which the torch is passed on, also LAMPADEPHORIA.
MALADMINISTERED	• maladministered v. Simple past tense and past participle of maladminister. • MALADMINISTER v. to administer wrongly.
MASTERMINDED	• masterminded v. Simple past tense and past participle of mastermind. • MASTERMIND v. to originate, think out, and direct.
MELODRAMATISED	• melodramatised v. Simple past tense and past participle of melodramatise. • MELODRAMATISE v. to make melodramatic, also MELODRAMATIZE.
MIDDLEBROWISM	• middlebrowism n. Middlebrow attitudes generally. • MIDDLEBROWISM n. the state of being middlebrow.
MIDDLEBROWISMS	• MIDDLEBROWISM n. the state of being middlebrow.
MISCOMPREHENDED	• miscomprehended v. Simple past tense and past participle of miscomprehend. • MISCOMPREHEND v. to comprehend wrongly.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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English Wiktionary: 182 words
Scrabble in French: 23 words
Scrabble in Spanish: 55 words
Scrabble in Italian: 104 words
Scrabble in German: no word
Scrabble in Romanian: 9 words

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