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There are 8 words containing 2D, 2S, T and 2U

DESUETUDESdesuetudes n. Plural of desuetude.
DESUETUDE n. disuse, discontinuance.
DISQUIETUDESdisquietudes n. Plural of disquietude.
DISQUIETUDE n. anxiety, agitation.
UNDERSTUDIESunderstudies n. Plural of understudy.
understudies v. Third-person singular simple present indicative form of understudy.
UNDERSTUDY v. to act another's part or take over another's duties.
DISUBSTITUTEDdisubstituted adj. (Organic chemistry) Having two substituents.
DISUBSTITUTED adj. having two substituent atoms or groups in a molecule.
UNDAUNTEDNESSundauntedness n. The state or condition of being undaunted.
UNDAUNTEDNESS n. the state of being undaunted.
DISADVENTUROUSdisadventurous adj. (Obsolete) Unfortunate; calamitous.
DISADVENTUROUS adj. (obsolete) unfortunate.
UNDAUNTEDNESSESUNDAUNTEDNESS n. the state of being undaunted.
UNDISTINGUISHEDundistinguished adj. Not distinguished: not marked by conspicuous qualities.
undistinguished adj. Not distinguished: not having an air of distinction.
UNDISTINGUISHED adj. not distinguished.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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