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There are 4 words containing 2D, P, 2R and 2S

DEPRESSURISEDdepressurised v. Simple past tense and past participle of depressurise.
DEPRESSURISE v. to reduce the air pressure in esp. suddenly, also DEPRESSURIZE.
DEPRESSURIZEDdepressurized v. Simple past tense and past participle of depressurize.
DEPRESSURIZE v. to reduce the air pressure in esp. suddenly, also DEPRESSURISE.
DEREPRESSEDderepressed v. Simple past tense and past participle of derepress.
derepressed adj. (Genetics, of a gene) activated by the removal of a repressor.
DEREPRESS v. to activate (a gene or enzyme) by releasing it from a blocked state.
RUDDERPOSTSrudderposts n. Plural of rudderpost.
RUDDERPOST n. the shank of a rudder, having the blade at one end and the attachments for operating it at the other.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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