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There are 18 words containing 2D, I, 2S and 2U

DECIDUOUSNESSdeciduousness n. The state or condition of being deciduous; the quality of trees which lose their leaves in winter or the dry season.
DECIDUOUSNESS n. the state of being deciduous.
DECIDUOUSNESSESDECIDUOUSNESS n. the state of being deciduous.
DESULFURISEDdesulfurised v. Simple past tense and past participle of desulfurise.
DESULFURISE v. to remove the sulfur from a compound, also DESULFURIZE, DESULPHURISE, DESULPHURIZE.
DESULPHURISEDdesulphurised v. Simple past tense and past participle of desulphurise.
DESULPHURISE v. to remove the sulphur from a compound, also DESULFURISE, DESULFURIZE, DESULPHURIZE.
DISADVENTUROUSdisadventurous adj. (Obsolete) Unfortunate; calamitous.
DISADVENTUROUS adj. (obsolete) unfortunate.
DISQUIETUDESdisquietudes n. Plural of disquietude.
DISQUIETUDE n. anxiety, agitation.
DISUBSTITUTEDdisubstituted adj. (Organic chemistry) Having two substituents.
DISUBSTITUTED adj. having two substituent atoms or groups in a molecule.
SCULDUDDERIESSCULDUDDERY n. (Scots) a breach of chastity; bawdy talk, also SCULDUDDRY, SKULDUDDERY.
SCULDUDDRIESSCULDUDDRY n. (Scots) a breach of chastity; bawdy talk, also SCULDUDDERY, SKULDUDDERY.
SKULDUDDERIESSKULDUDDERY n. (Scots) a breach of chastity; bawdy talk, also SCULDUDDERY, SCULDUDDRY.
UNDERSTUDIESunderstudies n. Plural of understudy.
understudies v. Third-person singular simple present indicative form of understudy.
UNDERSTUDY v. to act another's part or take over another's duties.
UNDERSUBSCRIBEDundersubscribed adj. Having too few subscribers or subscriptions.
undersubscribed v. Simple past tense and past participle of undersubscribe.
UNDERSUBSCRIBED adj. insufficiently subscribed.
UNDISCUSSEDundiscussed adj. Not discussed, not having been put under discussion.
UNDISCUSSED adj. not discussed.
UNDISGUISEDundisguised adj. Not disguised, plainly visible.
UNDISGUISED adj. not disguised or concealed.
UNDISGUISEDLYundisguisedly adv. In an undisguised manner; openly.
UNDISGUISED adv. not disguised or concealed.
UNDISTINGUISHEDundistinguished adj. Not distinguished: not marked by conspicuous qualities.
undistinguished adj. Not distinguished: not having an air of distinction.
UNDISTINGUISHED adj. not distinguished.
UNSUBSIDISEDunsubsidised adj. Alternative spelling of unsubsidized.
UNSUBSIDISED adj. not subsidised, also UNSUBSIDIZED.
UNSUBSIDIZEDunsubsidized adj. Not subsidized.
UNSUBSIDIZED adj. not subsidized, also UNSUBSIDISED.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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