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There are 13 words containing 2D, I, 2M and 2S

DESMODIUMS	• desmodiums n. Plural of desmodium. • DESMODIUM n. a plant of the telegraph-plant genus.
DISCOMMENDS	• discommends v. Third-person singular simple present indicative form of discommend. • DISCOMMEND v. to mention with disapprobation.
DISCOMMODES	• discommodes v. Third-person singular simple present indicative form of discommode. • DISCOMMODE v. to put to inconvenience, also INCOMMODE.
DISEMBOSOMED	• disembosomed v. Simple past tense and past participle of disembosom. • DISEMBOSOM v. to separate from the bosom, to unburden.
DARMSTADTIUMS	• DARMSTADTIUM n. an artificially produced radioactive element.
DISCOMMODIOUS	• discommodious adj. Not commodious; uncomfortable or inconvenient. • DISCOMMODIOUS adj. inconvenient.
DECOMMISSIONED	• decommissioned v. Simple past tense and past participle of decommission. • DECOMMISSION v. to remove (as a ship or nuclear power plant) from service.
DISCOMMODITIES	• discommodities n. Plural of discommodity. • DISCOMMODITY n. inconvenience.
DISEMBODIMENTS	• disembodiments n. Plural of disembodiment. • DISEMBODIMENT n. the state of being disembodied.
MIDDLEBROWISMS	• MIDDLEBROWISM n. the state of being middlebrow.
DISACCOMMODATES	• disaccommodates v. Third-person singular simple present indicative form of disaccommodate. • DISACCOMMODATE v. to put to inconvenience.
DISCOMMISSIONED	• discommissioned v. Simple past tense and past participle of discommission. • DISCOMMISSION v. (Milton) to deprive of a commission.
DISCOMMODIOUSLY	• discommodiously adv. In a discommodious manner. • DISCOMMODIOUS adv. inconvenient.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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English Wiktionary: 121 words
Scrabble in French: 16 words
Scrabble in Spanish: 56 words
Scrabble in Italian: 42 words
Scrabble in German: no word
Scrabble in Romanian: no word

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