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There are 20 words containing 2D, F, 2I and 2S

DISULFIDSdisulfids n. Plural of disulfid.
DISULFID n. a sulphide containing two atoms of sulphur to the molecule, also DISULFIDE, DISULPHIDE, DISULPHURET.
DISULFIDESdisulfides n. Plural of disulfide.
DISULFIDE n. a sulphide containing two atoms of sulphur to the molecule, also DISULFID, DISULPHIDE, DISULPHURET.
FIDDIOUSESFIDDIOUS v. (Shakespeare) to treat as leniently as Coriolanus treated Aufidius.
CADDISFLIEScaddisflies n. Plural of caddisfly.
caddis␣flies n. Plural of caddis fly.
CADDISFLY n. any small mothlike insect of the order Trichoptera that lives near, and lays its eggs in, water.
DISINFESTEDdisinfested v. Simple past tense and past participle of disinfest.
DISINFEST v. to remove infestation from.
DECLASSIFIEDdeclassified v. Simple past tense and past participle of declassify.
DECLASSIFY v. to remove or reduce the security classification of.
DECRASSIFIEDdecrassified v. Simple past tense and past participle of decrassify.
DECRASSIFY v. to make less crass or boorish.
DISFURNISHEDdisfurnished v. Simple past tense and past participle of disfurnish.
disfurnished adj. Deprived of furniture, accoutrements or belongings; stripped, destitute.
DISFURNISH v. to strip, render destitute.
DISSATISFIEDdissatisfied adj. Feeling or displaying disappointment or a lack of contentment.
dissatisfied adj. Not satisfied (e.g. with the quality of something).
dissatisfied v. Simple past tense and past participle of dissatisfy.
FIDDLESTICKSfiddlesticks interj. (Euphemistic) Nonsense! Expresses dismissal or disdain.
fiddlesticks interj. (Euphemistic) Darn! Expresses mild dismay or annoyance.
fiddlesticks n. Plural of fiddlestick.
DIGNIFIEDNESSDIGNIFIEDNESS n. the state of being dignified.
DISFRANCHISEDdisfranchised v. Simple past tense and past participle of disfranchise.
DISFRANCHISE v. to deprive of franchise.
DISDAINFULNESSdisdainfulness n. The state or quality of being disdainful.
DISDAINFUL n. full of or expressing disdain, also SDEIGNFULL.
DISSATISFIEDLYDISSATISFIED adv. DISSATISFY, to fail to satisfy.
DISSYLLABIFIEDdissyllabified adj. Alternative form of disyllabified.
DISSYLLABIFY v. to make disyllabic.
FORBIDDINGNESSforbiddingness n. The quality of being forbidding.
FORBIDDINGNESS n. the state of being forbidding.
SULFADIMIDINESSULFADIMIDINE n. a sulpha drug used in human and veterinary medicine.
DIGNIFIEDNESSESDIGNIFIEDNESS n. the state of being dignified.
DISENFRANCHISEDdisenfranchised v. Simple past tense and past participle of disenfranchise.
disenfranchised adj. Not represented; especially, not having the right to vote.
DISENFRANCHISE v. to deprive of a franchise.
DISFELLOWSHIPEDdisfellowshiped v. Simple past tense and past participle of disfellowship; alternative spelling of disfellowshipped.
DISFELLOWSHIP v. to exclude from fellowship.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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