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There are 20 words containing 2D, E, 2S and 2T

DASTARDLIESTdastardliest adj. Superlative form of dastardly: most dastardly.
DASTARDLY adj. like a dastard, despicable.
DISINTERESTEDdisinterested adj. Having no stake or interest in the outcome, and no conflicts of interest; free of bias, impartial.
disinterested adj. (Proscribed) Uninterested, lacking interest.
DISINTERESTED adj. having no personal stake.
DISINTERESTEDLYdisinterestedly adv. In a disinterested manner; impartially, dispassionately.
DISINTERESTED adv. having no personal stake.
DISSERTATEDdissertated v. Simple past tense and past participle of dissertate.
DISSERTATE v. to discourse.
DISTASTEDdistasted v. Simple past tense and past participle of distaste.
DISTASTE v. (archaic) to feel distaste for.
DISTORTEDNESSdistortedness n. The quality of being distorted.
DISTORTEDNESS n. the state of being distorted.
DISTORTEDNESSESDISTORTEDNESS n. the state of being distorted.
DISTRACTEDNESSdistractedness n. The state or quality of being distracted; distraction.
DISTRACTEDNESS n. the state of being distracted.
DISTRUSTEDdistrusted v. Simple past tense and past participle of distrust.
DISTRUST v. to have no trust in, also MISTRUST.
DISUBSTITUTEDdisubstituted adj. (Organic chemistry) Having two substituents.
DISUBSTITUTED adj. having two substituent atoms or groups in a molecule.
ENDODONTISTSendodontists n. Plural of endodontist.
ENDODONTIST n. a practitioner of endodontics.
MASTOIDITIDESmastoiditides n. Plural of mastoiditis.
MASTOIDITIS n. inflammation of mastoid cells.
OUTDATEDNESSoutdatedness n. The quality of being outdated.
OUTDATEDNESS n. the state of being outdated.
OUTDATEDNESSESOUTDATEDNESS n. the state of being outdated.
STADDLESTONEstaddle␣stone n. One of the mushroom-shaped stones used as a support for a barn (or staddle). The shape prevents rats…
STADDLESTONE n. a low mushroom-shaped arrangement of a conical and flat, circular stone, used as a support for a haystack.
STADDLESTONESstaddle␣stones n. Plural of staddle stone.
STADDLESTONE n. a low mushroom-shaped arrangement of a conical and flat, circular stone, used as a support for a haystack.
STADHOLDERATESstadholderates n. Plural of stadholderate.
STADHOLDERATE n. the office of stadholder, a Dutch viceroy or provincial governor, also STADHOLDERSHIP, STADTHOLDERATE, STADTHOLDERSHIP.
STADTHOLDERATESstadtholderates n. Plural of stadtholderate.
STADTHOLDERATE n. the office of stadtholder, also STADHOLDERATE, STADHOLDERSHIP, STADTHOLDERSHIP.
STADTHOLDERSstadtholders n. Plural of stadtholder.
STADTHOLDER n. (Dutch) a Dutch viceroy or provincial governor, also STADHOLDER.
STADTHOLDERSHIPstadtholdership n. (Historical) The office or rank of a stadtholder.
STADTHOLDERSHIP n. the office of stadtholder, also STADHOLDERATE, STADHOLDERSHIP, STADTHOLDERATE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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