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There are 7 words containing 2D, E, M, S and 2U

DEMUTUALISEDdemutualised v. Simple past tense and past participle of demutualise.
DEMUTUALISE v. of a mutual institution, to become a public company, also DEMUTUALIZE.
DISHUMOUREDdishumoured v. Simple past tense and past participle of dishumour.
DISHUMOUR v. (obsolete) to put out of humour.
DUMBFOUNDERSdumbfounders n. Plural of dumbfounder.
DUMBFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMFOUND, DUMFOUNDER.
DUMFOUNDERSdumfounders v. Third-person singular simple present indicative form of dumfounder.
DUMFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMBFOUNDER, DUMFOUND.
DUODENUMSduodenums n. Plural of duodenum.
DUODENUM n. (Latin) the first portion of the small intestine.
HUMDUDGEONShumdudgeons n. Plural of humdudgeon.
HUMDUDGEON n. (Scots) low spirits.
PSEUDOPODIUMpseudopodium n. (Cytology) pseudopod.
PSEUDOPODIUM n. a process protruding from the cell of a protozoan, etc., used for movement or feeding.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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