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There are 10 words containing 2D, E, M, 2S and Y

DOMESDAYSdomesdays n. Plural of domesday.
DOMESDAY n. a day of judgment, also DOOMSDAY.
DOOMSDAYERSdoomsdayers n. Plural of doomsdayer.
DOOMSDAYER n. one who prophesies doom, also DOOMSAYER.
DISMAYEDNESSdismayedness n. The state or quality of being dismayed.
DISMAYEDNESS n. the state of being dismayed.
HYDROMEDUSAShydromedusas n. Plural of hydromedusa.
HYDROMEDUSA n. a hydrozoan in its medusoid stage, also HYDROMEDUSAN, HYDROMEDUSOID.
MISADVISEDLYmisadvisedly adv. In a misadvised manner.
MISADVISED adv. MISADVISE, to advise wrongly.
DISCOMPOSEDLYdiscomposedly adv. In a discomposed manner.
DISCOMPOSED adv. DISCOMPOSE, to disarrange; to disturb.
HYDROMEDUSANSHYDROMEDUSAN n. a hydromedusa, also HYDROMEDUSA, HYDROMEDUSOID.
DISMAYEDNESSESDISMAYEDNESS n. the state of being dismayed.
EPIDIDYMITISESEPIDIDYMITIS n. inflammation of an epididymis.
HYDROMEDUSOIDSHYDROMEDUSOID n. a hydromedusa, also HYDROMEDUSA, HYDROMEDUSAN.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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See this list for:

  • English Wiktionary: 231 words
  • Scrabble in French: 7 words
  • Scrabble in Spanish: 11 words
  • Scrabble in Italian: no word
  • Scrabble in German: no word
  • Scrabble in Romanian: no word


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