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There are 18 words containing 2D, E, F, R and 2S

DISFORESTEDdisforested v. Simple past tense and past participle of disforest.
DISFOREST v. to clear of forest, also DISAFFOREST.
SEMIFREDDOSsemifreddos n. Plural of semifreddo.
SEMIFREDDO n. (Italian) a partially frozen Italian dessert similar to ice-cream.
DECRASSIFIEDdecrassified v. Simple past tense and past participle of decrassify.
DECRASSIFY v. to make less crass or boorish.
DEFORMEDNESSdeformedness n. (Obsolete, rare) The quality or state of being deformed.
DEFORMEDNESS n. the state of being deformed.
DESULFURISEDdesulfurised v. Simple past tense and past participle of desulfurise.
DESULFURISE v. to remove the sulfur from a compound, also DESULFURIZE, DESULPHURISE, DESULPHURIZE.
DISFURNISHEDdisfurnished v. Simple past tense and past participle of disfurnish.
disfurnished adj. Deprived of furniture, accoutrements or belongings; stripped, destitute.
DISFURNISH v. to strip, render destitute.
DISPROFESSEDdisprofessed v. Simple past tense and past participle of disprofess.
DISPROFESS v. to renounce the profession or pursuit of.
DREADFULNESSdreadfulness n. The characteristic of being dreadful.
DREADFULNESS n. the state of being dreadful.
DISAFFORESTEDdisafforested v. Simple past tense and past participle of disafforest.
DISAFFOREST v. to clear of forest, also DISFOREST.
DISFRANCHISEDdisfranchised v. Simple past tense and past participle of disfranchise.
DISFRANCHISE v. to deprive of franchise.
DEFORMEDNESSESDEFORMEDNESS n. the state of being deformed.
DREADFULNESSESdreadfulnesses n. Plural of dreadfulness.
DREADFULNESS n. the state of being dreadful.
FORBIDDINGNESSforbiddingness n. The quality of being forbidding.
FORBIDDINGNESS n. the state of being forbidding.
FOREHANDEDNESSforehandedness n. Prudence, foresight, and thriftiness.
forehandedness n. Action taken in advance.
forehandedness n. Wealth, the quality of having sufficient possessions to live comfortably.
FREEHANDEDNESSfreehandedness n. The quality or state of being freehanded.
free-handedness n. Alternative form of freehandedness.
FREEHANDED n. openhanded, liberal.
SCHADENFREUDESschadenfreudes n. Plural of schadenfreude.
SCHADENFREUDE n. (German) enjoyment gained from others' troubles.
UNFRIENDEDNESSunfriendedness n. (Archaic) friendlessness.
UNFRIENDEDNESS n. the state of being unfriended.
DISENFRANCHISEDdisenfranchised v. Simple past tense and past participle of disenfranchise.
disenfranchised adj. Not represented; especially, not having the right to vote.
DISENFRANCHISE v. to deprive of a franchise.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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