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There are 12 words containing 2D, E, F, M, S and U

DUFFERDOMSDUFFERDOM n. being a duffer, also DUFFERISM.
DEMULSIFIEDdemulsified v. Simple past tense and past participle of demulsify.
DEMULSIFY v. to separate from an emulsion.
DUMFOUNDERSdumfounders v. Third-person singular simple present indicative form of dumfounder.
DUMFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMBFOUNDER, DUMFOUND.
DEFRAUDMENTSdefraudments n. Plural of defraudment.
DEFRAUDMENT n. the act of defrauding.
DEHUMIDIFIESdehumidifies v. Third-person singular simple present indicative form of dehumidify.
DEHUMIDIFY v. to remove moisture from (as air).
DUMBFOUNDERSdumbfounders n. Plural of dumbfounder.
DUMBFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMFOUND, DUMFOUNDER.
BEFUDDLEMENTSbefuddlements n. Plural of befuddlement.
BEFUDDLEMENT n. the state of being befuddled.
DEHUMIDIFIERSdehumidifiers n. Plural of dehumidifier.
DEHUMIDIFIER n. an apparatus for reducing humidity.
SULFADIMIDINEsulfadimidine n. (Pharmacology) A particular sulfonamide antibacterial agent.
SULFADIMIDINE n. a sulpha drug used in human and veterinary medicine.
UNDISCOMFITEDundiscomfited adj. Not discomfited.
UNDISCOMFITED adj. not discomfited.
DIAMONDIFEROUSdiamondiferous adj. (Mineralogy) Yielding diamond.
DIAMONDIFEROUS adj. containing diamonds.
SULFADIMIDINESSULFADIMIDINE n. a sulpha drug used in human and veterinary medicine.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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