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There are 18 words containing 2D, E, F, M, O and S

DISFORMEDdisformed v. Simple past tense and past participle of disform.
DISFORM v. to alter the form of.
MISFOLDEDmisfolded v. Simple past tense and past participle of misfold.
misfolded adj. (Molecular biology, of a protein or nucleic acid) folded into an incorrect tertiary structure.
MISFOLD v. to fold wrongly.
DUFFERDOMSDUFFERDOM n. being a duffer, also DUFFERISM.
SEMIFREDDOsemifreddo n. Any dessert eaten cold but not frozen.
SEMIFREDDO n. (Italian) a partially frozen Italian dessert similar to ice-cream.
DISCOMFITEDdiscomfited v. Simple past tense and past participle of discomfit.
DISCOMFIT v. to disconcert or balk.
DISINFORMEDdisinformed v. Simple past tense and past participle of disinform.
DISINFORM v. to inform incorrectly, also MISINFORM.
DUMFOUNDERSdumfounders v. Third-person singular simple present indicative form of dumfounder.
DUMFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMBFOUNDER, DUMFOUND.
SEMIFREDDOSsemifreddos n. Plural of semifreddo.
SEMIFREDDO n. (Italian) a partially frozen Italian dessert similar to ice-cream.
DEFORMALISEDDEFORMALISE v. to make less formal, also DEFORMALIZE.
DEFORMEDNESSdeformedness n. (Obsolete, rare) The quality or state of being deformed.
DEFORMEDNESS n. the state of being deformed.
DISCOMFORTEDdiscomforted v. Simple past tense and past participle of discomfort.
DISCOMFORT v. to make uncomfortable or uneasy.
DISCONFIRMEDdisconfirmed v. Simple past tense and past participle of disconfirm.
DISCONFIRM v. to deny the validity of.
DUMBFOUNDERSdumbfounders n. Plural of dumbfounder.
DUMBFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMFOUND, DUMFOUNDER.
POSTMODIFIEDpostmodified v. Simple past tense and past participle of postmodify.
POSTMODIFY v. to modify the sense of (a word or phrase) by being placed after it.
FORMALDEHYDESformaldehydes n. Plural of formaldehyde.
FORMALDEHYDE n. a formic aldehyde, formalin.
UNDISCOMFITEDundiscomfited adj. Not discomfited.
UNDISCOMFITED adj. not discomfited.
DEFORMEDNESSESDEFORMEDNESS n. the state of being deformed.
DIAMONDIFEROUSdiamondiferous adj. (Mineralogy) Yielding diamond.
DIAMONDIFEROUS adj. containing diamonds.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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