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There are 17 words containing 2D, E, F, L and 2S

DISFLESHEDdisfleshed v. Simple past tense and past participle of disflesh.
DISFLESH v. (archaic) to reduce the flesh or obesity of.
DISULFIDESdisulfides n. Plural of disulfide.
DISULFIDE n. a sulphide containing two atoms of sulphur to the molecule, also DISULFID, DISULPHIDE, DISULPHURET.
OFFSADDLESoffsaddles v. Third-person singular simple present indicative form of offsaddle.
OFFSADDLE v. to unsaddle.
CADDISFLIEScaddisflies n. Plural of caddisfly.
caddis␣flies n. Plural of caddis fly.
CADDISFLY n. any small mothlike insect of the order Trichoptera that lives near, and lays its eggs in, water.
DECLASSIFIEDdeclassified v. Simple past tense and past participle of declassify.
DECLASSIFY v. to remove or reduce the security classification of.
DEFEUDALISESdefeudalises v. Third-person singular simple present indicative form of defeudalise.
DEFEUDALISE v. to deprive of feudal character, also DEFEUDALIZE.
DESULFURISEDdesulfurised v. Simple past tense and past participle of desulfurise.
DESULFURISE v. to remove the sulfur from a compound, also DESULFURIZE, DESULPHURISE, DESULPHURIZE.
DREADFULNESSdreadfulness n. The characteristic of being dreadful.
DREADFULNESS n. the state of being dreadful.
FIDDLESTICKSfiddlesticks interj. (Euphemistic) Nonsense! Expresses dismissal or disdain.
fiddlesticks interj. (Euphemistic) Darn! Expresses mild dismay or annoyance.
fiddlesticks n. Plural of fiddlestick.
PADDLEFISHESpaddlefishes n. Plural of paddlefish.
PADDLEFISH n. a member of the sturgeon family, aka spadefish.
FELDSPATHOIDSfeldspathoids n. Plural of feldspathoid.
FELDSPATHOID n. any mineral of a group related to feldspar, also FELSPATHOID, FOID.
DISDAINFULNESSdisdainfulness n. The state or quality of being disdainful.
DISDAINFUL n. full of or expressing disdain, also SDEIGNFULL.
DISSATISFIEDLYDISSATISFIED adv. DISSATISFY, to fail to satisfy.
DISSYLLABIFIEDdissyllabified adj. Alternative form of disyllabified.
DISSYLLABIFY v. to make disyllabic.
DREADFULNESSESdreadfulnesses n. Plural of dreadfulness.
DREADFULNESS n. the state of being dreadful.
SULFADIMIDINESSULFADIMIDINE n. a sulpha drug used in human and veterinary medicine.
DISFELLOWSHIPEDdisfellowshiped v. Simple past tense and past participle of disfellowship; alternative spelling of disfellowshipped.
DISFELLOWSHIP v. to exclude from fellowship.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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