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There are 13 words containing 2D, 2E, 2S and Y

DISPERSEDLYdispersedly adv. In a dispersed manner; in a scattered way, here and there.
DISPERSED adv. DISPERSE, to scatter.
DREADLESSLYdreadlessly adv. Without dread; fearlessly.
DREADLESS adv. free from dread.
HENDIADYSEShendiadyses n. Plural of hendiadys.
HENDIADYS n. the expression of an idea by two nouns connected by and (as cups and gold) instead of by a noun and an adjective (as golden cups).
DISMAYEDNESSdismayedness n. The state or quality of being dismayed.
DISMAYEDNESS n. the state of being dismayed.
DISPLEASEDLYdispleasedly adv. In a displeased manner.
DISPLEASED adv. DISPLEASE, to offend, to annoy.
DODECASTYLESdodecastyles n. Plural of dodecastyle.
DODECASTYLE n. a portico so built.
GLASSYHEADEDglassyheaded adj. (Rare) Bald, smooth-headed.
GLASSYHEADED adj. (Tennyson) with a shiny bald head.
DEHYDROGENASESdehydrogenases n. Plural of dehydrogenase.
DEHYDROGENASE n. an enzyme that accelerates the removal of hydrogen from metabolites and its transfer to other substances.
DEHYDROGENISESdehydrogenises v. Third-person singular simple present indicative form of dehydrogenise.
DEHYDROGENISE v. to remove hydrogen from, also DEHYDROGENIZE.
DISMAYEDNESSESDISMAYEDNESS n. the state of being dismayed.
EPIDIDYMITISESEPIDIDYMITIS n. inflammation of an epididymis.
DISINTERESTEDLYdisinterestedly adv. In a disinterested manner; impartially, dispassionately.
DISINTERESTED adv. having no personal stake.
DODECASYLLABLESdodecasyllables n. Plural of dodecasyllable.
DODECASYLLABLE n. a line of twelve syllables.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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See this list for:

  • English Wiktionary: 436 words
  • Scrabble in French: 83 words
  • Scrabble in Spanish: 26 words
  • Scrabble in Italian: no word
  • Scrabble in German: no word
  • Scrabble in Romanian: no word


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