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There are 18 words containing 2D, 2E, 2M and R

DEMIREPDOMdemirepdom n. The realm or sphere of demireps.
DEMIREPDOM n. the state of being a demirep, a woman of doubtful reputation.
DEMIREPDOMSDEMIREPDOM n. the state of being a demirep, a woman of doubtful reputation.
DISMEMBEREDdismembered v. Simple past tense and past participle of dismember.
dismembered adj. From which the limbs have been removed.
DISMEMBER v. to cut or tear a body limb from limb.
RECOMMENDEDrecommended v. Simple past tense and past participle of recommend.
RECOMMEND v. to commend or introduce as suitable for acceptance.
COMMANDEEREDcommandeered v. Simple past tense and past participle of commandeer.
COMMANDEER v. to compel to perform military service.
DEPROGRAMMEDdeprogrammed v. Simple past tense and past participle of deprogram.
DEPROGRAM v. to prevail on a person to reject obsessive beliefs, also DEPROGRAMME.
HAMMERHEADEDhammerheaded adj. Alternative form of hammer-headed.
hammer-headed adj. Having a head in the shape of a hammer.
hammer-headed adj. (Idiomatic) stupid, ignorant.
MASTERMINDEDmasterminded v. Simple past tense and past participle of mastermind.
MASTERMIND v. to originate, think out, and direct.
DISREMEMBEREDdisremembered v. Simple past tense and past participle of disremember.
DISREMEMBER v. to forget.
UNRECOMMENDEDunrecommended adj. Not recommended; discouraged.
UNRECOMMENDED adj. not recommended.
CHORDAMESODERMchordamesoderm n. (Anatomy) The axial mesoderm, which lies along the central axis under the neural tube and gives rise to the notochord.
CHORDAMESODERM n. the layer of specialized cells in the middle of a developing embryo which forms the notochord and structures of the central nervous system.
LAMPADEDROMIESLAMPADEDROMY n. a foot race with lighted torches, esp. a relay race in which the torch is passed on, also LAMPADEPHORIA.
MELODRAMATISEDmelodramatised v. Simple past tense and past participle of melodramatise.
MELODRAMATISE v. to make melodramatic, also MELODRAMATIZE.
MELODRAMATIZEDmelodramatized v. Simple past tense and past participle of melodramatize.
MELODRAMATIZE v. to make melodramatic, also MELODRAMATISE.
SLEDGEHAMMEREDsledgehammered v. Simple past tense and past participle of sledgehammer.
SLEDGEHAMMER v. to strike with a sledgehammer.
CHORDAMESODERMSCHORDAMESODERM n. the layer of specialized cells in the middle of a developing embryo which forms the notochord and structures of the central nervous system.
MALADMINISTEREDmaladministered v. Simple past tense and past participle of maladminister.
MALADMINISTER v. to administer wrongly.
MISCOMPREHENDEDmiscomprehended v. Simple past tense and past participle of miscomprehend.
MISCOMPREHEND v. to comprehend wrongly.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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