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There are 18 words containing 2D, 2E, 2G and S

DOGGEDESTdoggedest adj. Superlative form of dogged: most dogged.
DOGGED adj. stubbornly determined.
DISENGAGEDdisengaged v. Simple past tense and past participle of disengage.
disengaged adj. Not engaged; at leisure; free from occupation or attachment; unconnected; detached.
disengaged adj. (Dated) Not (socially) engaged; available, free.
DOGGEDNESSdoggedness n. The state of being dogged; persistence; perseverance; tenacity; stubbornness.
doggedness n. (Obsolete) sullenness; moroseness.
DOGGEDNESS n. the quality of being dogged.
RUGGEDISEDruggedised v. Simple past tense and past participle of ruggedise.
RUGGEDISE v. to make rugged, also RUGGEDIZE.
DOGGONEDESTdoggonedest adj. Superlative form of doggoned: most doggoned.
DOGGONED adj. damned, cursed.
HODGEPODGEShodgepodges n. Plural of hodgepodge.
hodge-podges n. Plural of hodge-podge.
HODGEPODGE n. a confused mass of ingredients shaken or mixed together in the same pot, also HOTCHPOT, HOTCHPOTCH.
DESEGREGATEDdesegregated v. Simple past tense and past participle of desegregate.
DESEGREGATE v. to eliminate segregation in.
DOGGEDNESSESdoggednesses n. Plural of doggedness.
DOGGEDNESS n. the quality of being dogged.
STRIDELEGGEDstridelegged v. Simple past tense and past participle of strideleg.
stridelegged adj. In a position astride something.
STRIDELEGGED adv. (Scots) astride, also STRIDELEGS.
DEGRADINGNESSdegradingness n. The state or quality of being degrading.
DEGRADINGNESS n. the state of being degrading.
DEGRINGOLADESdegringolades n. Plural of degringolade.
dégringolades n. Plural of dégringolade.
DEGRINGOLADE v. (French) to make a rapid descent.
DISAGGREGATEDdisaggregated v. Simple past tense and past participle of disaggregate.
DISAGGREGATE v. to separate into component parts.
EGGHEADEDNESSeggheadedness n. The quality of being eggheaded.
EGGHEADEDNESS n. the state of being eggheaded.
STRAIGHTEDGEDSTRAIGHTEDGED adj. having a straight edge.
DISENGAGEDNESSdisengagedness n. The state or quality of being disengaged.
DISENGAGEDNESS n. the state of being disengaged.
DEGRADINGNESSESDEGRADINGNESS n. the state of being degrading.
DEHYDROGENISINGdehydrogenising v. Present participle of dehydrogenise.
DEHYDROGENISE v. to remove hydrogen from, also DEHYDROGENIZE.
EGGHEADEDNESSESEGGHEADEDNESS n. the state of being eggheaded.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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