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There are 4 eight-letter words containing D, E, I, N and 3S

DISNESTSdisnests v. Third-person singular simple present indicative form of disnest.
DISNEST v. to dislodge from a nest.
DISSENTSdissents n. Plural of dissent.
dissents v. Third-person singular simple present indicative form of dissent.
DISSENT v. to disagree.
MISSENDSmissends v. Third-person singular simple present indicative form of missend.
MISSEND v. to send incorrectly.
SYNDESISsyndesis n. (Orthopedics, surgery) Synonym of arthrodesis (fusion of a joint between two or more bones).
syndesis n. (Cytology) Synapsis (association of homologous maternal and paternal chromosomes).
syndesis n. (Grammar) The use of a syndetic construction.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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