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There are 8 eight-letter words containing D, 2E, I, 2N and S

ADENINESadenines n. Plural of adenine (multiple adenine molecules).
ADENINE n. one of the four bases in DNA.
ANDESINEandesine n. (Mineralogy) Sodium calcium aluminum silicate, (𝑁𝑎𝑥𝐶𝑎𝑥𝐴𝑙𝑆𝑖3𝑂8), a plagioclase feldspar, the third member…
ANDESINE n. a kind of triclinic feldspar found in the Andes.
DENIZENSdenizens n. Plural of denizen.
denizens v. Third-person singular simple present indicative form of denizen.
DENIZEN v. to naturalize a person, word or expression.
DENTINESdentines n. Plural of dentine.
DENTINE n. the hard substance forming the body of a tooth, also DENTIN.
DESINENTdesinent adj. (Obsolete) Ending; forming an end; lowermost.
DESINENT adj. terminal; ending, also DESINENTIAL.
ENSIGNEDensigned v. Simple past tense and past participle of ensign.
ENSIGN v. to mark with a badge or sign.
INCENSEDincensed adj. Enraged; infuriated; spitefully or furiously angry.
incensed v. Simple past tense and past participle of incense.
INCENSE v. to make very angry.
SINNEREDSINNER v. to transgress, to act as a sinner.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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