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There are 4 eight-letter words containing 2D, 2E, I, N and S

DESIGNEDdesigned v. Simple past tense and past participle of design.
designed adj. Created according to a design.
designed adj. (Dated) Planned; designated.
DESTINEDdestined adj. Confined to a predetermined fate or destiny; certain.
destined v. Simple past tense and past participle of destine.
DESTINE v. to determine beforehand.
NEDDIESTNEDDY adj. like a ned, a hooligan.
SDEIGNEDsdeigned v. Simple past tense and past participle of sdeign.
SDEIGNE v. (obsolete) to disdain, also SDAINE, SDAYN, SDEIGN, SDEIN.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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