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There are 12 eight-letter words containing 2D, 3E, N and R

DEADENERdeadener n. Something that deadens.
DEADENER n. one that deadens.
DECERNEDdecerned v. Simple past tense and past participle of decern.
DECERN v. to decree by judicial sentence.
DEFENDERdefender n. Someone who defends people or property.
defender n. (Sports) One of the players whose primary task is to prevent the opposition from scoring.
defender n. A fighter who seeks to repel an attack.
DEGENDERdegender v. (Intransitive, obsolete) To degenerate.
degender v. (Transitive) To strip of gender; to make genderless or gender-neutral.
DEGENDER v. (Spenser) to degenerate.
ENDEAREDendeared v. Simple past tense and past participle of endear.
ENDEAR v. to make beloved.
FENDEREDfendered adj. Having a specified kind or number of fenders.
FENDERED adj. having a fender.
GENDEREDgendered v. Simple past tense and past participle of gender (“assign gender to”).
gendered v. (Archaic) simple past tense and past participle of gender (“engender”).
gendered adj. (Linguistics, of a language) Having grammatical gender.
REDDENEDreddened v. Simple past tense and past participle of redden.
reddened adj. Made red.
REDDEN v. to make or become red.
REDENIEDredenied v. Simple past tense and past participle of redeny.
REDENY v. to deny again.
REMENDEDremended v. Simple past tense and past participle of remend.
REMEND v. to mend again.
RENDEREDrendered v. Simple past tense and past participle of render.
RENDER v. to plaster with a first coat.
TENDEREDtendered v. Simple past tense and past participle of tender.
TENDER v. to offer.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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