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There are 16 fifteen-letter words containing 2D, 2E and 3N

ANDROSTENEDIONEandrostenedione n. (Biochemistry, steroids) A steroid sex hormone C19H26O2 that is secreted by the testes, ovaries, and…
CONDESCENDENCEScondescendences n. Plural of condescendence.
CONDESCENDENCE n. voluntary descent from one's rank or dignity in relations with an inferior.
CONDESCENDINGLYcondescendingly adv. In a condescending manner.
CONDESCENDING adv. CONDESCEND, to descend to a less formal or dignified level.
DEMANDINGNESSESDEMANDINGNESS n. the state of being demanding.
DISCOUNTENANCEDdiscountenanced v. Simple past tense and past participle of discountenance.
discountenanced adj. Deprecated.
discountenanced adj. Disliked.
INTERDEPENDENCEinterdependence n. The condition of being interdependent.
INTERDEPENDENCE n. the state of being interdependent, also INTERDEPENDENCY.
INTERDEPENDENCYinterdependency n. A mutual dependence, connection or correlation.
INTERDEPENDENCY n. the state of being interdependent, also INTERDEPENDENCE.
INTERDEPENDENTSSorry, definition not available.
MADDENINGNESSESMADDENINGNESS n. the state of being maddening.
NONCREDENTIALEDnoncredentialed adj. (US) Alternative spelling of noncredentialled.
NONCREDENTIALED adj. not having credentials.
NONINDEPENDENCEnonindependence n. Lack of independence; dependence.
NONINDEPENDENCE n. not independence.
UNBOUNDEDNESSESUNBOUNDEDNESS n. the state of being unbounded.
UNDAUNTEDNESSESUNDAUNTEDNESS n. the state of being undaunted.
UNDEMANDINGNESSundemandingness n. The quality of being undemanding; lack of difficulty or challenge.
UNDERHANDEDNESSunderhandedness n. The characteristic of being underhanded.
under-handedness n. Alternative form of underhandedness.
UNDERHANDEDNESS n. the state of being underhanded.
UNFOUNDEDNESSESUNFOUNDEDNESS n. the state of being unfounded.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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