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There are 3 fifteen-letter words containing 2D, 2E, F, N and R

DEDIFFERENTIATEdedifferentiate v. To lose or reverse differentiation.
DEDIFFERENTIATE v. to effect dedifferentiation, a change by which specialized tissue with several cell types reverts to a generalized and simpler form.
DISENFRANCHISEDdisenfranchised v. Simple past tense and past participle of disenfranchise.
disenfranchised adj. Not represented; especially, not having the right to vote.
DISENFRANCHISE v. to deprive of a franchise.
FEATHERBEDDINGSFEATHERBEDDING n. protecting (an industry, workers, etc.) by such practices as overmanning in order to save jobs.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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