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There are 13 fifteen-letter words containing 2D, 4E and I

BIGHEADEDNESSESBIGHEADEDNESS n. the state of being bigheaded.
DEDIFFERENTIATEdedifferentiate v. To lose or reverse differentiation.
DEDIFFERENTIATE v. to effect dedifferentiation, a change by which specialized tissue with several cell types reverts to a generalized and simpler form.
DEDUCIBLENESSESDEDUCIBLENESS n. the state of being deducible.
DELIGHTEDNESSESDELIGHTEDNESS n. the state of being delighted.
DISPERSEDNESSESDISPERSEDNESS n. the state of being dispersed.
INTERDEPENDENCEinterdependence n. The condition of being interdependent.
INTERDEPENDENCE n. the state of being interdependent, also INTERDEPENDENCY.
INTERDEPENDENCYinterdependency n. A mutual dependence, connection or correlation.
INTERDEPENDENCY n. the state of being interdependent, also INTERDEPENDENCE.
INTERDEPENDENTSSorry, definition not available.
NONINDEPENDENCEnonindependence n. Lack of independence; dependence.
NONINDEPENDENCE n. not independence.
PIGHEADEDNESSESpigheadednesses n. Plural of pigheadedness.
PIGHEADEDNESS n. PIGHEADED, obstinate.
PINHEADEDNESSESPINHEADEDNESS n. PINHEADED, stupid.
PSEUDOEPHEDRINEpseudoephedrine n. (Pharmacology) A sympathomimetic alkaloid commonly used as a decongestant; a chemical compound, an isomer…
PSEUDOEPHEDRINE n. a naturally occurring isomer of ephedrine, used in the form of its hydrochloride as a bronchodilator.
UNDECIDEDNESSESUNDECIDEDNESS n. the state of being undecided.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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