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There are 17 twelve-letter words containing D, 2E, N, O and 2P

APPENDECTOMYappendectomy n. (Surgery) The surgical procedure for the removal of the vermiform appendix.
APPENDECTOMY n. the surgical removal of the appendix, also APPENDICECTOMY.
DOPPELGANGERdoppelganger n. A ghostly double of a living person, especially one that haunts such a person.
doppelganger n. An evil twin.
doppelganger n. A remarkably similar double.
HEDGEHOPPINGhedgehopping v. Present participle of hedgehop.
hedgehopping n. The action or pastime of hedgehopping.
hedge-hopping v. Present participle of hedge-hop.
INTERCROPPEDintercropped v. Simple past tense and past participle of intercrop.
INTERCROP v. to plant a second crop between the rows of the first.
LEPIDOPTERANlepidopteran n. Any insect of the order Lepidoptera, the butterflies and moths.
lepidopteran adj. Characteristic of these insects.
LEPIDOPTERAN n. an insect such as moth or butterfly, also LEPIDOPTERON.
LEPIDOPTERONlepidopteron n. (Zoology) Any insect of the order Lepidoptera.
LEPIDOPTERON n. any of numerous insects of the order Lepidoptera, typically having two pairs of wings covered with fragile scales, also LEPIDOPTERAN.
NEUROPEPTIDEneuropeptide n. (Biochemistry) Any of several peptides, such as endorphins, that function as neurotransmitters.
NEUROPEPTIDE n. a peptide that influences neural activity or functioning.
NEWSPAPERDOMnewspaperdom n. The realm or sphere of newspaper publishing or journalism.
NEWSPAPERDOM n. the world of newspapers.
OPPIGNERATEDoppignerated v. Simple past tense and past participle of oppignerate.
OPPIGNERATE v. (obsolete) to pawn, also OPPIGNORATE.
PREAPPOINTEDpreappointed v. Simple past tense and past participle of preappoint.
PREAPPOINT v. to appoint previously, or beforehand.
PREPONDERANTpreponderant adj. Having greater or the greatest weight, quantity, importance or force.
PREPONDERANT adj. having superior weight, force, or influence.
PREPONDERATEpreponderate v. (Transitive) To outweigh; to be heavier than; to exceed in weight.
preponderate v. (Transitive) To overpower by stronger or moral power.
preponderate v. (Transitive, obsolete) To cause to prefer; to incline; to decide.
PREPORTIONEDpreportioned v. Simple past tense and past participle of preportion.
preportioned adj. Divided into portions in advance.
pre-portioned v. Simple past tense and past participle of pre-portion.
UNDERPEOPLEDunderpeopled adj. Short of people; underpopulated.
UNDERPEOPLED adj. underpopulated.
UNDERPROPPEDunderpropped v. Simple past tense and past participle of underprop.
UNDERPROP v. to prop from beneath.
UNDERPROPPERunderpropper n. One who, or that which, underprops or supports.
UNDERPROPPER n. one who underprops.
UNPROPERTIEDunpropertied adj. Not propertied; not having property.
UNPROPERTIED adj. not propertied.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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