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There are 19 twelve-letter words containing 2D, 2E, L, S and Y

BADDELEYITESbaddeleyites n. Plural of baddeleyite.
BADDELEYITE n. zirconium dioxide, occurring as colourless, yellow, brown, or black monoclinic crystals.
DESPONDENTLYdespondently adv. In a despondent manner.
DESPONDENT adv. feeling or showing extreme discouragement.
DIGLYCERIDESdiglycerides n. Plural of diglyceride.
DIGLYCERIDE n. an ester formed from glycerol.
DISENTRAYLEDDISENTRAYLE v. (Spenser) to disembowel, remove the entrails, also DISENTRAIL.
DISORDEREDLYdisorderedly adv. In a disordered way; haphazardly, chaotically.
DISORDERED adv. DISORDER, to disarrange.
DISPLEASEDLYdispleasedly adv. In a displeased manner.
DISPLEASED adv. DISPLEASE, to offend, to annoy.
DISQUIETEDLYDISQUIETED adv. DISQUIET, to deprive of quiet, rest, or peace.
DODECASTYLESdodecastyles n. Plural of dodecastyle.
DODECASTYLE n. a portico so built.
FURALDEHYDESFURALDEHYDE n. either of two aldehydes derived from furan.
GLASSYHEADEDglassyheaded adj. (Rare) Bald, smooth-headed.
GLASSYHEADED adj. (Tennyson) with a shiny bald head.
MEDDLESOMELYmeddlesomely adv. In a meddlesome manner.
MEDDLESOME adv. given to meddling.
METALDEHYDESMETALDEHYDE n. a polymer of acetaldehyde.
PARALDEHYDESparaldehydes n. Plural of paraldehyde.
PARALDEHYDE n. a sleep-inducing drug.
SLEEPYHEADEDSLEEPYHEADED adj. given to sleep.
SOFTHEADEDLYsoftheadedly adv. In a softheaded manner.
SOFTHEADED adv. having or indicative of a weak, unrealistic, or uncritical mind.
SOREHEADEDLYSOREHEADED adv. irritable, grumpy.
UNDESERVEDLYundeservedly adv. In an undeserved manner.
UNDESERVED adv. UNDESERVE, to fail to deserve.
UNDESIGNEDLYundesignedly adv. In a way that was not designed; as an unexpected consequence; unintentionally.
UNDESIGNED adv. not designed.
UNDIVESTEDLYUNDIVESTED adv. not divested.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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See this list for:

  • English Wiktionary: 48 words
  • Scrabble in French: 4 words
  • Scrabble in Spanish: no word
  • Scrabble in Italian: no word
  • Scrabble in German: no word
  • Scrabble in Romanian: no word


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