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There are 19 twelve-letter words containing 2D, 2E, L, P and S

DECAPSULATEDdecapsulated v. Simple past tense and past participle of decapsulate.
DECAPSULATE v. to remove a capsule from (a part or organ, esp. the kidney).
DEDUPLICATESdeduplicates v. Third-person singular simple present indicative form of deduplicate.
DEDUPLICATE v. to remove (duplicated material) from a system.
DESPONDENTLYdespondently adv. In a despondent manner.
DESPONDENT adv. feeling or showing extreme discouragement.
DISENVELOPEDdisenveloped v. Simple past tense and past participle of disenvelop.
DISENVELOP v. to free from that in which a thing is enveloped.
DISPLEASEDLYdispleasedly adv. In a displeased manner.
DISPLEASED adv. DISPLEASE, to offend, to annoy.
DISPLEASUREDdispleasured v. Simple past tense and past participle of displeasure.
DISPLEASURE v. (archaic) to displease.
DISPLENISHEDdisplenished v. Simple past tense and past participle of displenish.
DISPLENISH v. to deprive or strip, as a house of furniture, or a barn of stock.
LOPSIDEDNESSlopsidedness n. The state or property of being lopsided.
LOPSIDEDNESS n. the state of being lopsided.
MISDEVELOPEDmisdeveloped v. Simple past tense and past participle of misdevelop.
MISDEVELOP v. to develop wrongly.
PADDLEFISHESpaddlefishes n. Plural of paddlefish.
PADDLEFISH n. a member of the sturgeon family, aka spadefish.
PARALDEHYDESparaldehydes n. Plural of paraldehyde.
PARALDEHYDE n. a sleep-inducing drug.
PEBBLEDASHEDpebbledashed v. Simple past tense and past participle of pebbledash.
pebble-dashed v. Simple past tense and past participle of pebble-dash.
pebble␣dashed v. Simple past tense and past participle of pebble dash.
POSTDEADLINEpostdeadline adj. After a deadline.
POSTDEADLINE adj. following a deadline.
PRESCHEDULEDprescheduled v. Simple past tense and past participle of preschedule.
PRESCHEDULE v. to schedule in advance.
RELANDSCAPEDrelandscaped v. Simple past tense and past participle of relandscape.
RELANDSCAPE v. to landscape again.
SIMPLEMINDEDsimpleminded adj. Stupid.
simpleminded adj. Unsophisticated; lacking subtlety.
simple-minded adj. Lacking subtlety or sophistication.
SLEEPYHEADEDSLEEPYHEADED adj. given to sleep.
SPLENDIDNESSsplendidness n. The state or the quality of being splendid.
splendidness n. Something that is splendid.
SPLENDIDNESS n. the state of being splendid.
SPREADEAGLEDspreadeagled v. Simple past tense and past participle of spreadeagle.
spread-eagled v. Simple past tense and past participle of spread-eagle.
spread-eagled adj. In a spread eagle position.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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