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There are 8 twelve-letter words containing 2D, 2E, I and 2M

DECOMMUNISEDdecommunised v. Simple past tense and past participle of decommunise.
DECOMMUNISE v. to remove communist politics or influence from (a person or country), also DECOMMUNIZE.
DECOMMUNIZEDdecommunized v. Simple past tense and past participle of decommunize.
de-communized v. Simple past tense and past participle of de-communize.
de-Communized v. Simple past tense and past participle of de-Communize.
DEMIMONDAINEdemimondaine n. A sexually promiscuous woman (of the demimonde).
demi-mondaine n. Alternative form of demimondaine.
DEMIMONDAINE n. (French) a demirep, a woman of doubtful reputation.
DISCOMMENDEDdiscommended v. Simple past tense and past participle of discommend.
DISCOMMEND v. to mention with disapprobation.
DISEMBOSOMEDdisembosomed v. Simple past tense and past participle of disembosom.
DISEMBOSOM v. to separate from the bosom, to unburden.
MASTERMINDEDmasterminded v. Simple past tense and past participle of mastermind.
MASTERMIND v. to originate, think out, and direct.
MEDICAMENTEDMEDICAMENT v. to treat with a medicament.
SIMPLEMINDEDsimpleminded adj. Stupid.
simpleminded adj. Unsophisticated; lacking subtlety.
simple-minded adj. Lacking subtlety or sophistication.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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