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There are 16 twelve-letter words containing 2D, 2E, H, S and T

DECAHYDRATESdecahydrates n. Plural of decahydrate.
DECAHYDRATE n. a compound containing ten molecules of water of crystallization.
DEHYPNOTISEDdehypnotised v. Simple past tense and past participle of dehypnotise.
DEHYPNOTISE v. to free from hypnosis, also DEHYPNOTIZE.
DENDRACHATESdendrachates n. Plural of dendrachate.
DENDRACHATE n. moss agate.
DETACHEDNESSdetachedness n. The state or quality of being detached.
DETACHEDNESS n. the state of being detached.
DISBURTHENEDdisburthened v. Simple past tense and past participle of disburthen.
DISBURTHEN v. to get rid of a burden, also DISBURDEN.
DISENCHANTEDdisenchanted v. Simple past tense and past participle of disenchant.
DISENCHANT v. to free from enchantment.
DISENTHRONEDdisenthroned v. Simple past tense and past participle of disenthrone.
DISENTHRONE v. (Milton) to dethrone.
DISHEARTENEDdisheartened adj. Discouraged, despairing.
disheartened v. Simple past tense and past participle of dishearten.
DISHEARTEN v. to cause to lose spirit or morale.
DISINHERITEDdisinherited v. Simple past tense and past participle of disinherit.
DISINHERIT v. to deprive of an inheritance, also DISHERIT.
METALDEHYDESMETALDEHYDE n. a polymer of acetaldehyde.
SEMIDETACHEDsemidetached adj. Alternative spelling of semi-detached.
semidetached n. Alternative spelling of semi-detached.
semi-detached adj. Of a house: joined to another one on one side, having one shared wall.
SOFTHEADEDLYsoftheadedly adv. In a softheaded manner.
SOFTHEADED adv. having or indicative of a weak, unrealistic, or uncritical mind.
THUNDERHEADSthunderheads n. Plural of thunderhead.
THUNDERHEAD n. a thunder cloud.
UNDERSHIRTEDundershirted adj. Wearing an undershirt.
UNDERSHIRTED adj. wearing an undershirt.
UNDESPATCHEDundespatched adj. Alternative spelling of undispatched.
UNDESPATCHED adj. not despatched.
UNMETHODISEDUNMETHODISED adj. not methodised, also UNMETHODIZED.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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