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There are 4 twelve-letter words containing 2D, 2E, G, M and R

DEFRAGMENTEDdefragmented v. Simple past tense and past participle of defragment.
DEFRAGMENT v. to run a program which reduces or eliminates the fragmentation of (a file or disk) by bringing together parts of files stored in separate locations to a single location on the disk.
DEGLAMORISEDdeglamorised v. Simple past tense and past participle of deglamorise.
DEGLAMORISE v. to remove the glamour from, also DEGLAMORIZE.
DEGLAMORIZEDdeglamorized v. Simple past tense and past participle of deglamorize.
DEGLAMORIZE v. to remove the glamour from, also DEGLAMORISE.
DEPROGRAMMEDdeprogrammed v. Simple past tense and past participle of deprogram.
DEPROGRAM v. to prevail on a person to reject obsessive beliefs, also DEPROGRAMME.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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