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There are 12 twelve-letter words containing 2D, 2E, F, R and U

DEFRAUDMENTSdefraudments n. Plural of defraudment.
DEFRAUDMENT n. the act of defrauding.
DEHUMIDIFIERdehumidifier n. A device for removing the moisture content from air.
DEHUMIDIFIER n. an apparatus for reducing humidity.
DESULFURATEDdesulfurated v. Simple past tense and past participle of desulfurate.
DESULFURATE v. to remove the sulphur from.
DESULFURISEDdesulfurised v. Simple past tense and past participle of desulfurise.
DESULFURISE v. to remove the sulfur from a compound, also DESULFURIZE, DESULPHURISE, DESULPHURIZE.
DESULFURIZEDdesulfurized v. Simple past tense and past participle of desulfurize.
DESULFURIZE v. to remove the sulphur from a compound, also DESULFURISE, DESULPHURISE, DESULPHURIZE.
DREADFULNESSdreadfulness n. The characteristic of being dreadful.
DREADFULNESS n. the state of being dreadful.
DUMFOUNDEREDdumfoundered v. Simple past tense and past participle of dumfounder.
DUMFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMBFOUNDER, DUMFOUND.
FOREGROUNDEDforegrounded v. Simple past tense and past participle of foreground.
FOREGROUND v. to bring to the foreground, the part of a picture or field of view nearest the observer's eye.
FURALDEHYDESFURALDEHYDE n. either of two aldehydes derived from furan.
UNBEFRIENDEDunbefriended adj. Not befriended; lacking friends.
UNBEFRIENDED adj. not befriended.
UNDERFEEDINGunderfeeding v. Present participle of underfeed.
underfeeding n. Inadequate feeding.
UNDERFEEDING n. the act of feeding inadequately.
UNDERSTAFFEDunderstaffed adj. Having an inadequate number of workers or assistants.
UNDERSTAFFED adj. inadequately staffed.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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