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There are 9 twelve-letter words containing 2D, 2E, F, N and S

CODEFENDANTScodefendants n. Plural of codefendant.
co-defendants n. Plural of co-defendant.
CODEFENDANT n. a joint defendant.
DEFIBRINISEDDEFIBRINISE v. to deprive of fibrin, also DEFIBRINIZE.
DEFORMEDNESSdeformedness n. (Obsolete, rare) The quality or state of being deformed.
DEFORMEDNESS n. the state of being deformed.
DEFRAUDMENTSdefraudments n. Plural of defraudment.
DEFRAUDMENT n. the act of defrauding.
DESANCTIFIEDdesanctified v. Simple past tense and past participle of desanctify.
DIFFUSEDNESSdiffusedness n. The state or quality of being diffused.
DIFFUSEDNESS n. the state of being diffused.
DREADFULNESSdreadfulness n. The characteristic of being dreadful.
DREADFULNESS n. the state of being dreadful.
UNDERSTAFFEDunderstaffed adj. Having an inadequate number of workers or assistants.
UNDERSTAFFED adj. inadequately staffed.
UNFEUDALISEDunfeudalised v. Simple past tense and past participle of unfeudalise.
UNFEUDALISE v. to deprive of a feudal character, also UNFEUDALIZE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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