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There are 16 twelve-letter words containing 2D, 3E, M and S

DEBRIDEMENTSdebridements n. Plural of debridement.
débridements n. Plural of débridement.
DEBRIDEMENT n. (French) the surgical removal of dead, infected tissue or foreign matter from a wound.
DECOMPRESSEDdecompressed v. Simple past tense and past participle of decompress.
DECOMPRESS v. to release from pressure or compression.
DEFORMEDNESSdeformedness n. (Obsolete, rare) The quality or state of being deformed.
DEFORMEDNESS n. the state of being deformed.
DEMAGNETISEDdemagnetised v. Simple past tense and past participle of demagnetise.
DEMAGNETISE v. to remove the magnetic property from, also DEMAGNETIZE.
DEMENTEDNESSdementedness n. The quality of being demented.
DEMENTEDNESS n. the state of being demented.
DENDROMETERSdendrometers n. Plural of dendrometer.
DENDROMETER n. an instrument for measuring trees.
DISEMBOWELEDdisemboweled v. Simple past tense and past participle of disembowel.
DISEMBOWEL v. to take out the bowels of.
DISEMPOWEREDdisempowered v. Simple past tense and past participle of disempower.
DISEMPOWER v. to deprive of power; to divest of strength.
ENDODERMISESENDODERMIS n. a close-set sheath, one cell thick, enclosing the central cylinder in plants.
INTERMEDDLESintermeddles v. Third-person singular simple present indicative form of intermeddle.
INTERMEDDLE v. to meddle, to interfere.
MEDDLESOMELYmeddlesomely adv. In a meddlesome manner.
MEDDLESOME adv. given to meddling.
METALDEHYDESMETALDEHYDE n. a polymer of acetaldehyde.
MINDEDNESSESmindednesses n. Plural of mindedness.
MINDEDNESS n. an inclination to do something.
MISDELIVEREDmisdelivered v. Simple past tense and past participle of misdeliver.
MISDEVELOPEDmisdeveloped v. Simple past tense and past participle of misdevelop.
MISDEVELOP v. to develop wrongly.
SEMIDETACHEDsemidetached adj. Alternative spelling of semi-detached.
semidetached n. Alternative spelling of semi-detached.
semi-detached adj. Of a house: joined to another one on one side, having one shared wall.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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